Disruption of methyl group metabolism by ethanol.

Disruption of GAL1 Gene in Saccharomyces cerevisiae Leads to Higher Ethanol Production

Substrate Specificity and Alkyl Group Selectivity in the Metabolism of TV-Nitrosodialkylamines1

Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we character ized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of ¿Y-nitrosodimethylamine. In this work, we investigated the metabolism of other .•V-nitrosndialkylamim-s in rat liver microsomes and in...

Substrate specificity and alkyl group selectivity in the metabolism of N-nitrosodialkylamines.

Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work, we investigated the metabolism of other N-nitrosodialkylamines in rat liver microsomes and in recons...

EFFECT OF AEROBIC TRAINING AND ETHANOL CONSUMPTION ON LIPID PROFILE AND GENE EXPRESSION OF SOME GASTROCNEMIUS MUSCLE MYOKINES IN MALE RATS

Background: Skeletal muscle as an endocrine tissue is involved in the regulation of metabolic activity, production and secretion of hormones including myokines. The aim of the present study was to investigate the effect of eight weeks of aerobic training combined with ethanol consumption on plasma lipid profile and glucose levels, triglyceride content and mayonectin, irisin and leptin gene expr...

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway

Methyl groups are important for numerous cellular functions such as DNA methylation, phosphatidylcholine synthesis, and protein synthesis. The methyl group can directly be delivered by dietary methyl donors, including methionine, folate, betaine, and choline. The liver and the muscles appear to be the major organs for methyl group metabolism. Choline can be synthesized from phosphatidylcholine ...